Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 11;12:636403. doi: 10.3389/fendo.2021.636403

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Devesa

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Ghrelin production by the stomach and effects of ghrelin on pituitary GH synthesis and secretion. (1)In fasting situations, an empty stomach increases ghrelin production in specific P/DI cells (2) in humans located in oxyntic cells. Then, ghrelin is released into the circulation (3, 4) from where it reaches (5) the pituitary gland, inducing the synthesis and secretion of GH (6). Circulating ghrelin also reaches the hypothalamus (7), where it induces stimulation (8) of the appetite neurons, GHRH, and inhibits the release of SS. (9)Furthermore, circulating ghrelin inhibits the inhibitory effects of IGF-I on the synthesis and pituitary secretion of GH (10). In turn, IGF-I inhibits the increase in circulating ghrelin (11) produced in response to fasting. Blue arrows: stimulation; Red arrows: Inhibition; Yellow arrow: synthesis and secretion of GH; Black arrow: Hypothalamic effects of ghrelin; +, stimulation; −, inhibition.