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. 2021 Mar 11;12:636403. doi: 10.3389/fendo.2021.636403

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Copyright © 2021 Devesa

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nesfatins and GH secretion. Nesfatins are involved in suppressing food intake, although they also have many different endocrine effects. Therefore, it is logical that in GH cells cultured with ghrelin, which induces the expression of pit-1 and GH (blue arrows), the addition of nesfatins to the medium blocks, if not totally to a great extent, these effects of ghrelin on pit-1 and GH (red arrows), although its effects in intensity and time vary depending on the nesfatin used. The mechanism by which nesfatins induce these effects appears to be the downregulation of cAMP/PKA/CREB. NESF, nesfatin-1; NLP, nesfatin-1-like peptide.