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Effects of klotho on GH secretion and vice versa.
| Level | Effect |
|---|---|
| Anterior Pituitary | + Phosphorylation of ERK ½ |
| Paracrine induction of GH secretion | |
| Inhibits the inhibitory effect of IGF-I | |
| Plasma levels of klotho | Decreased in untreated GH-deficient patients |
| GH administration recovers normal values of klotho |
+, Stimulates.
