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. 2021 Mar 11;12:641656. doi: 10.3389/fimmu.2021.641656

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Copyright © 2021 Gómez Delgado, Corvillo, Nozal, Arjona, Madrid, Melgosa, Bravo, Szilágyi, Csuka, Veszeli, Prohászka and Sánchez-Corral.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lectin recognition of FH and desialylated FH. (A) Western-blot analysis with polyclonal anti-FH antibodies. “In vitro” desialylated FH (dFH) has the same molecular weight than FH in a plasma sample from patient H837 obtained 1 day after disease onset (sp1), and lower than FH in the sample obtained at remission (sp2). (B) Differential recognition of FH and dFH by lectin RNA (which recognizes non-reducing terminal beta-D-galactose), and lectin SNA (which binds primarily to Neu5Ac(α2–6) Gal/GalNAc disaccharide sequences). (C) Schematics of FH showing the SCR domains with N-linked carbohydrates; the sugar composition of the carbohydrate molecule is based on Schmidt et al. (32).