Table 2. Categorization of HPD Definitions Proposed in the Included Studies According to the Concept of Tumor Growth Acceleration.

Category	Parameters of tumor growth acceleration	Evaluating lesions	Consideration of TTF	Source
1	TGR ratio (post-TGR/pre-TGR)a	Target lesions only	TTF <2 mo	Tunali et al,22 2019
			None	Champiat et al,5 2017; Ferrara et al,6 2018; Aoki et al,10 2019; Kanjanapan et al,14 2019; Scheiner et al,202019; Ten Berge et al,21 2019; Matos et al,18 2020c; Kim et al,15 2019c; Arasanz et al,23 2020; Petrioli et al,25 2020
2	TGK ratio (post-TGK/pre-TGK)b	Target lesions only	None	Saâda-Bouzid et al,9 2017; Ji et al,12 2019; Lu et al,17 2019; Refae et al,26 2020
3	Early tumor burden increase	Target lesions only	TTF <2 mo	Ruiz-Patiño et al,27 2020
			None	Abbas et al,28 2019; Forschner et al,24 2020
		Target and new lesions	TTF <2 mo	Lo Russo et al,16 2019; Matos et al,18 2020c
4	Both TGK ratio and early tumor burden increase	Target lesion only	TTF <2 mo	Kato et al,8 2017; Kamada et al,13 2019
			None	Sasaki et al,19 2019
	Both TGR ratio and early tumor burden increase	Target and new lesions	TTF <2 mo	Hwang et al,11 2020; Kim et al,15 2019c
	Either TGR ratio or TGK ratio	Target lesion only	None	Kim et al,7 2019

Abbreviations: HPD, hyperprogressive disease; TGK, tumor growth kinetics; TGR, tumor growth rate; TTF, time to failure.

^aPost-TGR/pre-TGR calculated by tumor volume.

^bPost-TGK/pre-TGK calculated by tumor size.

^cMatos et al¹⁸ and Kim et al¹⁵ compared 2 HPD definitions.