Table 2.
Descriptive statistics for all the proteins assessed.
| A | B | C | D | E | ||||
|---|---|---|---|---|---|---|---|---|
| Protein | Time 1 (pg/mL) | Time 2 (pg/mL) | Wilcoxon Signed Ranked Test p-values | |||||
| Median | IQR | Median | IQR | Overall | LVLVs | IVLVs | HVLVs | |
| GM-CSF | 0.247 | 0.154 | 0.252 | 0.148 | 0.629 | 0.432 | 0.61 | 0.695 |
| IL-1α | 0.318 | 0.961 | 0.13 | 0.499 | 0.162 | 0.236 | 0.624 | 0.722 |
| IL-5 | 0.755 | 1.022 | 0.767 | 0.886 | 0.339 | 0.77 | 0.492 | 0.193 |
| IL-7 | 1.279 | 0.573 | 1.306 | 1.016 | 0.792 | 0.695 | 0.695 | 0.922 |
| IL-12/IL-23p40 | 84.18 | 86.74 | 72.94 | 61.74 | 0.164 | 0.432 | 1 | 0.084 |
| IL-15 | 1.494 | 1.914 | 1.355 | 2.045 | 0.502 | 0.919 | 0.636 | 0.407 |
| IL-16 | 216.6 | 118.9 | 205.1 | 148.5 | 0.641 | 0.846 | 0.625 | 0.232 |
| TNF | 0.164 | 0.102 | 0.159 | 0.08 | 0.175 | 0.103 | 0.922 | 0.492 |
| IFN-γ | 5.577 | 5.834 | 6.08 | 3.984 | 0.245 | 0.695 | 0.77 | 0.01 |
| IL-1β | 0.112 | 0.06 | 0.119 | 0.053 | 0.764 | 0.141 | 1 | 0.636 |
| IL-2 | 0.403 | 0.356 | 0.303 | 0.307 | 0.202 | 0.695 | 0.636 | 0.16 |
| IL-4 | 0.041 | 0.035 | 0.043 | 0.062 | 0.665 | 0.492 | 0.193 | 0.636 |
| IL-6 | 0.851 | 0.701 | 1.074 | 0.83 | 0.245 | 0.037 | 0.232 | 0.131 |
| IL-10 | 0.992 | 1.409 | 0.706 | 0.808 | 0.012 | 0.064 | 0.492 | 0.084 |
| IL-12p70 | 0.143 | 0.291 | 0.169 | 0.245 | 0.863 | 0.432 | 0.922 | 0.407 |
| IL-13 | 0.69 | 4.281 | 0.974 | 2.534 | 0.903 | 0.557 | 0.846 | 0.625 |
| IL-1Rα | 106.6 | 97.5 | 96.12 | 89.15 | 0.262 | 0.492 | 0.922 | 0.131 |
| IL-17A | 3.058 | 2.193 | 2.802 | 1.457 | 0.171 | 0.557 | 0.625 | 0.084 |
| IL-17AF | 2.043 | 2.281 | 2.143 | 1.428 | 0.968 | 0.77 | 0.77 | 0.625 |
| IL-17B | 0.952 | 0.684 | 1.058 | 0.894 | 0.428 | 1 | 1 | 0.084 |
| IL-17C | 3.065 | 4.577 | 1.943 | 4.364 | 0.07 | 0.006 | 0.557 | 0.922 |
| IL-17D | 14.68 | 10.25 | 13.69 | 9.831 | 0.761 | 0.625 | 0.557 | 0.625 |
| Eotaxin | 99.99 | 37.99 | 91.61 | 67.6 | 0.584 | 1 | 0.846 | 0.322 |
| MIP-1β | 24.13 | 13.78 | 25.5 | 20.39 | 0.871 | 0.922 | 0.695 | 0.846 |
| Eotaxin3 | 14.73 | 11.03 | 13.9 | 12.95 | 0.67 | 0.846 | 0.625 | 0.557 |
| TARC | 42.4 | 36.19 | 39.67 | 37.17 | 0.109 | 0.432 | 0.432 | 0.375 |
| IP-10 | 264.3 | 265.9 | 258.3 | 211 | 0.984 | 0.625 | 0.131 | 0.193 |
| MIP-1α | 9.032 | 4.086 | 8.558 | 4.78 | 0.655 | 0.232 | 0.77 | 1 |
| IL-8 | 138.8 | 102.5 | 108.4 | 106.3 | 0.99 | 1 | 0.722 | 0.922 |
| MCP-1 | 80.6 | 29.55 | 76.76 | 35.29 | 0.516 | 0.492 | 0.846 | 0.77 |
| MDC | 666.7 | 263.8 | 711.3 | 434.7 | 0.245 | 0.492 | 0.625 | 0.695 |
| MCP-4 | 17.2 | 9.422 | 17.08 | 10.46 | 0.371 | 0.131 | 0.77 | 0.625 |
| MIP-3α | 7.554 | 4.884 | 5.984 | 4.640 | – | – | – | – |
| VEGF | 11.01 | 6.808 | 10.61 | 5.739 | 0.67 | 1 | 0.77 | 0.922 |
| VEGFC | 7.471 | 13.21 | 10.14 | 18.31 | 0.221 | 0.695 | 0.625 | 0.322 |
| VEGFD | 154.6 | 204.5 | 127.7 | 196.1 | 0.328 | 0.77 | 0.846 | 0.492 |
| Tie2 | 2636 | 3500 | 2644 | 4066 | 0.777 | 0.232 | 0.625 | 0.922 |
| Flt-1 | 16.54 | 36.8 | 19.7 | 31.68 | 0.503 | 0.846 | 0.922 | 0.275 |
| PIGF | 0.585 | 2.367 | 0.734 | 2.384 | 0.73 | 0.625 | 0.492 | 0.846 |
| βFGF | 0.592 | 1.014 | 0.67 | 1.435 | 0.213 | 0.432 | 0.232 | 1 |
| SAA | 1219000 | 2977000 | 1384000 | 13780000 | 0.135 | 0.375 | 0.027 | 0.492 |
| CRP | 1029000 | 3681000 | 1455000 | 6862000 | 0.158 | 0.432 | 0.027 | 0.432 |
| VCAM1 | 658600 | 334200 | 617900 | 168700 | 0.02 | 0.492 | 0.16 | 0.16 |
| ICAM1 | 518300 | 287700 | 551800 | 258800 | 0.839 | 0.922 | 0.695 | 1 |
| IL-3 | 6.858 | 7.636 | 6.777 | 6.496 | 0.57 | 0.432 | 0.322 | 0.432 |
| IL-9 | 0.502 | 0.415 | 0.476 | 0.299 | 0.213 | 0.922 | 0.432 | 0.193 |
| TSLP | 0.75 | 0.488 | 0.706 | 0.413 | 0.158 | 0.064 | 0.432 | 0.695 |
| IL-21 | 1.723 | 2.404 | 0.872 | 1.828 | 0.08 | 0.286 | 0.183 | 0.636 |
| IL-31 | 0.117 | 0.123 | 0.088 | 0.104 | 0.114 | 0.131 | 0.322 | 1 |
| IL-27 | 1425 | 431.2 | 1554 | 677 | 0.855 | 1 | 0.557 | 0.232 |
| IL-23 | 0.359 | 8.859 | 0.359 | 3.284 | 0.74 | 0.813 | 0.371 | 1 |
| IL-22 | 1.61 | 5.837 | 2.356 | 6.818 | 0.641 | 0.322 | 0.625 | 0.492 |
(A): Median and IQR shown at each timepoint for all 30 volunteers. (B–E): The null hypothesis of the difference between the two time points assessed was assessed using Wilcoxon Signed Ranks tests for all volunteers (B), LVLVs (C), HVLVs (D) and HVLVs (E). p-values below 0.05 were interpreted to be significant. Proteins are presented by broad functional groups. Bold values indicate where p values are less than 0.05.