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. 2021 Mar 11;12:636267. doi: 10.3389/fendo.2021.636267

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Copyright © 2021 Jannapureddy, Sharma, Yepuri, Schmidt and Ramasamy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme showing competition between AR and HDAC3 for the DAD of SMRT/NCOR1 and consequent transcriptional changes leading to lipid accumulation. [adapted from (128)]. AR denotes aldose reductase; DAD refers to deacetylation domain of the nuclear corepressors, SMRT refers to silencing mediator of retinoic and thyroid receptor, NCOR1 denotes nuclear corepressor 1, RAR denotes retinoic acid receptor, HDAC3 denotes histone deacetylase 3.