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. 2021 Mar 11;12:636267. doi: 10.3389/fendo.2021.636267

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Copyright © 2021 Jannapureddy, Sharma, Yepuri, Schmidt and Ramasamy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme displays the impact of AR on changes in NAD⁺/NADH and consequent changes in glycolysis, mitochondrial properties and key signaling pathways leading to ischemic injury in hearts. ATP- adenosine triphosphate; JAK2- Janus activated kinase 2; MPTP-mitochondrial permeability transition pore, Akt- a serine/threonine-specific protein also known as Protein kinase B (PKB), pAkt- phosphorylated Akt, GSK3β-Glycogen synthase kinase 3 beta, STAT5- Signal transducer and activator of transcription 5.