TABLE 1.
Sugar alcohols and functional sugars produced by engineering Y. lipolytica.
| Products | Carbon source | Genetic engineering strategy | Cultivation Strategy | Titer | References |
| Glycerol | The overexpressed codon optimized bacterial hemoglobin from Vitreoscilla stercoraria was used | Bioreactor culture | 55.75 g/L | Mironczuk et al., 2019 | |
| Glycerol | Overexpressed TKL1 and GUT1, Disruption of EYK1 | Bioreactor culture | 80.6 g/L | Carly et al., 2017; Carlya et al., 2017 | |
| Glycerol | Ultraviolet (UV) mutagenesis and optimal C:N ratio | Chemostat culture | 113.1 g/L | Rakicka et al., 2017a | |
| Erythritol | Glycerol | The overexpression of Erythrose reductase encoding gene YALI0F18590gwas used | Batch culture | 44.44 g/L | Janek et al., 2017 |
| Glycerol | The four genes ZWF1, TAL1, GND1, and TKL1 were functionally overexpressed | Shake flask experiment | 51.09 g/L | Mironczuk et al., 2017 | |
| Glycerol | The disruption of Gene encoding erythrulose kinase YALI0F01606g was used | Batch bioreactor | 35.7 g/L | Carly et al., 2017; Carlya et al., 2017 | |
| Glycerol | Span 20 surfactant was added | Fed-batch culture | 142 g/L | Rakicka et al., 2017b | |
| D-threitol | Glucose | The overexpression of xylitol dehydrogenase gene (Ss-XDH) from Scheffersomyces stipitis | Culture broth | 112 g/L | Chi et al., 2019 |
| Isomaltulose | Sucrose | Displaying sucrose isomerase encoding gene from Pantoea dispersa UQ68J (PdSIase) on the Y. lipolytica cell surface | Fermentor | 465 g/L | Li et al., 2017 |
| Sucrose | gene encoding sucrose isomerase (SIase) from Pantoea dispersaUQ68J | Fermentor | 572.1 g/L | Zhang et al., 2018 | |
| Trehalose | Maltose | Displaying encoding trehalose synthase gene (TreS) on the Y. lipolytica cell surface | Bioreactor | 219 g/L | Li et al., 2016 |
| Fructo-oligosaccharides | Sucrose | Erythritol producing Y. lipolytica cells containing displayed fructosyltransferase | Bioreactor | 480 g/L | Zhang et al., 2016 |
| Inulin | The overexpression of optimized endo-inulinase gene from Aspergillus nigerwas used | Bioreactor | 546.6 g/L | Han et al., 2017 | |
| Galacto-oligosaccharides | lactose | Displaying β-galactosidase on Y. liplytica cell surface | Bioreactor | 160 g/L | An et al., 2016 |