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A schematic of breast tumor metastasis. (A) Metastatic tumor cells release extracellular mediators into the circulation. (B) Pro-inflammatory cytokines released from primary tumors induce upregulation of endothelial adhesion molecules at the secondary site. (C) Metastatic tumor cells leave the primary tumor and enter the circulation. (D) Tumor cells adhere to and migrate through endothelial cells through upregulated adhesion molecules at the secondary site and proliferate.
