. 2021 Mar 24;157(5):1–6. doi: 10.1001/jamadermatol.2021.0326

Table 3. Associations Between cirAE Features and irAE Types.

Characteristic	OR (95% CI)	P value
Organ class of irAE
Endocrine irAE
cirAE morphologic characteristic (psoriasiform)^b	4.54 (1.21-17.04)	.03^a
cirAEseverity	0.83 (0.34-2.03)	.68
GI irAE
cirAE morphologic characteristic (mucositis)^b	5.70 (1.11-29.40)	.04^a
cirAEseverity	1.74 (0.72-4.20)	.22
Hepatobiliary irAE
cirAE morphologic characteristic^c	NS	NS
cirAEseverity	0.44 (0.10-1.98)	.28
Pulmonary irAE
cirAE morphologic characteristic^c	NS	NS
cirAEseverity	1.3 (0.41-4.11)	.65
Rheumatologic irAE
cirAE morphologic characteristic (mucositis)^b	7.87 (1.18-52.74)	.03^e
cirAEseverity	0.27 (0.03-2.07)	.21
Specific irAE diagnosis
Thyroiditis
cirAE morphologic characteristic (psoriasiform)^d	3.68 (0.93-14.51)	.06^f
cirAEseverity	0.59 (0.19-1.80)	.35
Gastroenterocolitis
cirAE morphologic characteristic (mucositis)^d	6.80 (1.24-37.39)	.03^a
cirAEseverity	1.69 (90.67-4.26)	.26
Arthritis
cirAE morphologic characteristic (mucositis)^d	7.96 (1.18-53.62)	.03^e
cirAEseverity	0.31 (0.40-2.46)	.27

Abbreviations: cirAE, cutaneous immune-related adverse event; GI, gastrointestinal; irAE, noncutaneous immune-related adverse event; NS, not significant; OR, odds ratio.

^{^a}

P values remained statistically significant with 2-sided P value beneath the critical value, as defined using the false discovery rate control method, with a false discovery rate of 0.15.¹⁴ ICI regimen was significant only in analyses of gastrointestinal irAEs and gastroenterocolitis.

^{^b}

Provided OR is for mucositis or psoriasiform first cirAE relative to reference category of maculopapular reaction in multivariate model adjusted for age, sex, ICI regimen (statistically significant to P < .05), and cancer type (statistically significant to P < .05).

^{^c}

Associations between specific morphologic characteristics of first cirAE and hepatobiliary irAE, pulmonary irAE, ocular irAE, and other irAE were not significant.

^{^d}

Provided OR is for psoriasiform or mucositis first cirAE relative to the reference category of maculopapular reaction in multivariate model adjusted for age, sex, ICI regimen (statistically significant to P < .05), and cancer type (statistically significant to P < .05).

^{^e}

The association between mucositis and rheumatologic irAE, and mucositis and arthritis had P values below the significance threshold of P < .05, but their significance did not remain after accounting for the issue of multiple hypothesis testing using the false discovery rate control method.⁴

^{^f}

Patients with psoriasis as their first cirAE trended toward increased rates of thyroiditis, but this did not reach statistical significance.