Figure 2. Associations Between Change in New York Heart Association (NYHA) Class and Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OS) With Clinical Outcomes Among Patients With Heart Failure (HF) With Reduced Ejection in Contemporary US Outpatient Practice.

Unadjusted and adjusted hazard ratios indicating the risk of adverse clinical outcomes associated with improvement in NYHA class and improvement in KCCQ-OS. Adjusted models include age, sex, race/ethnicity, total household income, body mass index, systolic blood pressure, heart rate, ejection fraction, glomerular filtration rate, atrial fibrillation, coronary artery disease, diabetes, chronic obstructive pulmonary disease, prior heart failure hospitalization, cardiac resynchronization therapy, implantable cardioverter-defibrillator, angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker, sacubitril/valsartan, evidence-based β-blocker, and mineralocorticoid receptor antagonist.