. 2021 Apr;21(4):537–545. doi: 10.1016/S1473-3099(20)30432-1

Table 1.

The number of mother–child pairs reported in each analysed study by clinical outcome, presence of laboratory marker of congenital infection, and MIP status

		PCR-confirmed, by trimester of infection				PCR-negative, by trimester of infection
		1	2	3	Not reported	1	2	3	Not reported
Pomar et al (2018)¹⁶
CZS
	LMCI present	2	3	0	..	..	..	..	..
	LMCI absent	0	0	0	..	..	..	..	..
OPZRO
	LMCI present	5	19	6	..	..	..	..	..
	LMCI absent	9	13	4	..	..	..	..	..
No symptoms
	LMCI present	9	22	10	..	..	..	..	..
	LMCI absent	43	98	48	..	..	..	..	..
	Total mother–child pairs	68	155	68	..	..	..	..	..
Nogueira et al (2018)¹⁸
CZS
	LMCI present	0	0	0	..	..	..	..	..
	LMCI absent	0	0	0	..	..	..	..	..
OPZRO
	LMCI present	1	2	5	..	..	..	..	..
	LMCI absent	0	2	4	..	..	..	..	..
No symptoms
	LMCI present	1	6	3	..	..	..	..	..
	LMCI absent	2	16	12	..	..	..	..	..
Total mother–child pairs		4	26	24	..	..	..	..	..
Spanish cohort (PCR-negative patients reported as having a probable MIP)^*
CZS
LMCI present		0	1	0	..	0	0	0	..
LMCI absent		2	0	0	..	0	0	0	..
OPZRO
LMCI present		1^†	0	0	..	0	0	0	..
LMCI absent		0	1^†	0	..	6 + 1^†	6	7	..
No symptoms
LMCI present		0	0	0	..	0	0	0	..
LMCI absent		2	6	1	..	28	48	53	..
Total mother–child pairs		5	8	1	..	35	54	60	..
Hoen et al (2018)¹⁷
CZS		13	3	1	..	..	..	..	..
OPZRO		11	6	5	..	..	..	..	..
No symptoms		165	243	108	..	..	..	..	..
Total mother–child pairs		189	252	114	..	..	..	..	..
Brasil et al (2016; PCR negative patients showed no evidence of MIP)¹⁵
CZS		2	5	0	..	0	0	0	..
OPZRO		4 + 5^†	29 + 3^†	9 + 1^†	..	3	2	1 + 1^†	..
No symptoms		9	34	24	..	1	33	20	..
Total mother–child pairs		20	71	34	..	4	35	22	..
Conners et al (2018; PCR-negative patients reported as having a suspected MIP)²⁰ ^‡
LMCI present		..	..	..	7	..	..	..	11
LMCI absent		..	..	..	73	..	..	..	196
Total mother–child pairs		..	..	..	80	..	..	..	207
Merriam et al (2020; PCR-negative patients reported as having a presumed MIP)²¹ ^‡
CZS		..	..	..	1	..	..	..	0
OPZRO		..	..	..	1 + 1^†	..	..	..	6 + 1^†
No symptoms		..	..	..	13	..	..	..	47
Total mother–child pairs		..	..	..	16	..	..	..	54

CZS=congenital Zika syndrome. MIP=maternal infection in pregnancy. LMCI=laboratory markers of congenital infection. OPZRO=other potentially Zika-virus-related outcome.

These unpublished data were provided by author AS-A. The protocol was published previously.¹⁹^,²²

^†

Fetal losses with undetermined or unreported clinical categorisation.

^‡

For proportions of patients with confirmed or suspected infection in each trimester see the appendix (p 4).