Fig. 8.

Summary of the effects observed in pairwise combinations of different classes of tested POP mixtures by mathematical modelling. Each square summarizes the effects induced by the pairwise combinations of different classes of POPs (i.e., PerF + Br, PerF + Cl, or Br + Cl) on the selected DNT endpoints after 14 days and 28 days of treatment with the three tested concentrations (0.5, 1 and 1000x). Blue lines indicate additive effects observed with all the three concentrations, according to the Loewe non-interaction model. Red dashed lines represent potentiated (synergistic or antagonistic) effects observed with at least one of the three tested concentrations of combined POPs mixtures. (For interpretation of the references to colour in the Figure, the reader is referred to the web version of this article).