Table 3.

Comparison of metabolic variables between Lean NGT, ObOw-LI and ObOw-HI during fasting in the POEM cohort

	Lean NGT vs. ObOw-LI				Lean NGT vs. ObOw-HI
	Male		Female		Male		Female
	Mean difference (CI)	p-value	Mean difference (CI)	p-value	Mean difference (CI)	p-value	Mean difference (CI)	p-value
BMI (kg/m²)	-6.8 (-7.8; -5.7)	<0.001	-8.9 (-9.8; -7.9)	<0.001	-7.9 (-9.2; -6.6)	<0.001	-14.3 (-16.3; -12.4)	<0.001
Fat mass (%)	-7.8 (-9.7; -5.8)	<0.001	-13.0 (-14.8; -11.1)	<0.001	-11.0 (-13.4; -8.5)	<0.001	-16.2 (-19.8; -12.6)	<0.001
fS-Insulin (mU/l)	-0.3 (-3.4; 2.8)	0.971	-1.1 (-4.1; 1.8)	0.630	-11.0 (-14.9; -7.1)	<0.001	-15.1 (-21.0; -9.3)	<0.001
fP-C-peptide (nmol/l)	-0.13 (-0.21; -0.06)	<0.001	-0.15 (-0.22; -0.07)	<0.001	-0.37 (-0.47; -0.28)	<0.001	-0.49 (-0.64; -0.34)	<0.001
fB-Glucose (mmol/l)	0.0 (-0.1; 0.2)	0.739	0.0 (-0.1; 0.2)	0.832	0.0 (-0.3; 0.1)	0.474	0.1 (-0.2; 0.4)	0.682
fP-FFA (mmol/l)	-0.07 (-0.17; 0.03)	0.194	-0.03 (-0.12; 0.06)	0.748	-0.11 (-0.23; 0.01)	0.079	-0.18 (-0.36; 0.00)	0.048

BMI: body mass index; FFA: free fatty acids.

Results from sex-stratified Dunnett´s post hoc test following 2-way ANOVA presented in Fig. 5.

P-value < 0.05 is considered statistically significant.