Table 3. List of Significantly Enriched Genes and Proteins between the Young and Old Groups Obtained from the Enriched Pathways by PANTHER.

enriched pathways	proteins	genes
angiogenesis (P00005)	α-crystallin B chain, heat shock protein β-2	Cryab, Hspb2
CCKR signaling map (P06959)	acetyl-CoA acetyltransferase	Acat1
de novo purine biosynthesis (P02738)	adenylate kinase isoenzyme 1, adenylosuccinate synthetase isozyme 1	Ak1, Adssl1
gonadotropin-releasing hormone receptor pathway (P06664)	annexin A5	Anxa5
heterotrimeric G-protein signaling pathway—Gi α and Gs α mediated pathway (P00026)	glycogen synthase	Gys1
TCA cycle (P00051)	2-oxoglutarate dehydrogenase	Ogdh
VEGF signaling pathway (P00056)	α-crystallin B chain, heat shock protein β-2	Cryab, Hspb2
vitamin D metabolism and pathway (P04396)	vitamin D-binding protein	Gc
Wnt signaling pathway (P00057)	adenylosuccinate synthetase isozyme 1	Adssl1