Table 1.
Characteristics of the included studies in systemic review and meta-analysis.
| Study | Country | Totalpatients | Severe patients |
Non-severe patients |
||
|---|---|---|---|---|---|---|
| Age, years a | Male | Age, years a | Male | |||
| Argenziano MG | United States | 1000 | 62 (52–72) | 158 | 64 (51–77) | 353 |
| Cao J | China | 244 | 62.20 ± 13.43 | 63 | 59.79 ± 13.49 | 44 |
| Cao Z | China | 80 | 71 ± 15 | 16 | 44 ± 16 | 22 |
| Du RH | China | 109 | 68.4 ± 9.7 | 36 | 72.7 ± 11.6 | 38 |
| Ferguson J | United States | 72 | NA | NA | NA | NA |
| Giustino G | United States | 305 | 66 (56–74) | 132 | 58 (47–70) | 73 |
| Gregoriano C | Switzerland | 99 | 69 (57–75) | 28 | 63.5 (56–76) | 34 |
| Guan WJ | China | 1099 | 52 (40–65) | 100 | 45 (34–57) | 537 |
| Guo T | China | 187 | 71.4 (9.43) | 34 | 53.53 (13.22) | 57 |
| Hong KS | Korea | 98 | 63.2 ± 10.1 | 6 | 54.2 ± 17.7 | 32 |
| Huang C | China | 41 | 49 (41–61) | 11 | 49 (41–57.5) | 19 |
| Huang R | China | 202 | 49 (35–59) | 17 | 44 (33–53) | 99 |
| Israelsen SB | Denmark | 175 | 68 (60–72) | 16 | 73 (55–83) | 69 |
| Khamis F | Oman | 63 | 50 ± 17 | 21 | 47 ± 16 | 32 |
| Li C | China | 2068 | 69 (60–78) | 282 | 61 (49–68) | 723 |
| LI K | China | 83 | 53.7 ± 12.3 | 15 | 41.9 ± 10.6 | 29 |
| Li X | China | 548 | 65 (54–72) | 153 | 56 (44–66) | 126 |
| Lv Z | China | 354 | 62 (25–89) | 77 | 61 (23–79) | 58 |
| Omrani AS | Qatar | 5000 | 49.5 (39.5–60) | 100 | 38 (30–49) | 1067 |
| Ortiz-Brizuela E | Mexico | 309 | 53 (40–64) | 20 | 48 (29–60.5) | 65 |
| Pellaud C | Switzerland | 196 | 65 (56–71) | 30 | 74 (61–83) | 89 |
| Popov GT | Bulgaria | 138 | 63.0 ± 12.8 | 33 | 48.3 ± 15.7 | 54 |
| Shahriarirad R | Iran | 113 | NA | 7 | NA | 64 |
| Shi S | China | 416 | 74 (34–95) | 44 | 60 (21–90) | 161 |
| Suleyman G | United States | 463 | 63.8 ± 5.4 | 80 | 59.8 ± 15.2 | 85 |
| Tabata S | Japan | 104 | 73 (55–77) | 17 | 60 (40–71) | 22 |
| Tian S | China | 262 | 61.4 (1–94) | 26 | 44.5 (1–93) | 101 |
| Turcotte JJ | United States | 117 | 70.2 ± 12.1 | 26 | 62.6 ± 16.9 | 36 |
| Wan S | China | 135 | 56 (52–73) | 21 | 44 (33–49) | 52 |
| Wang D | China | 138 | 66 (57–78) | 22 | 51 (37–62) | 53 |
| Wang W | China | 421 | 56 (45–63) | 28 | 51 (38–60) | 186 |
| Wang Y | China | 222 | 70 (65.5–80) | 12 | 60.5 (48–67) | 96 |
| Wang Z | China | 69 | 70.5 (62–77) | 7 | 37 (32–51) | 25 |
| Wei Y | China | 276 | 65 (60–72.8) | 10 | 50 (39–57) | 145 |
| Wu J | China | 280 | 63.04 ± 10.20 | 45 | 37.55 ± 17.10 | 106 |
| Xiong F | China | 131 | 64.3 ± 12.4) | 17 | 63.1 ± 13.4 | 58 |
| Xiong S | China | 116 | 64 (53–76) | 38 | 56 (37–64) | 42 |
| Yang L | China | 200 | 71 ± 13.4 | 16 | 52 ± 16.2 | 82 |
| Zhang G | China | 221 | 62 (52–74) | 35 | 51 (36–64.3) | 73 |
| Zhang JJ | China | 140 | 64 (25–87) | 33 | 51.5 (26–78) | 38 |
| Zhou J | China | 201 | 57 (46–66) | 27 | 40 (31–53) | 75 |
a
Age data presented as median (IQR) or mean ± SD.