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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Nat Struct Mol Biol. 2021 Jan 18;28(2):181–189. doi: 10.1038/s41594-020-00548-4

Extended Data Figure 4. Distance distribution obtained using DEER on double-MTSL-labeled EBOV MPER/TM and G660L in POPC liposomes.

Extended Data Figure 4

A) Background-corrected DEER data for WT (green) and G660L (purple) EBOV MPER/TM in POPC liposomes. B) Distance distributions obtained by a best fit to the data in (A). As seen with the bicelle data (Fig 3), the addition of the G660L mutation causes a shift towards longer distance elements consistent with an opening of the MPER/TM angle. Measurements were performed at pH 5.5.