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. 2021 Mar 10;6(11):7815–7828. doi: 10.1021/acsomega.1c00308

Figure 3.

Figure 3

(A) Schematic illustration of mitochondrial active ETC complexes. NADH as a source of electron to start the electron transfer through various complexes to produce ATP in the absence of BBT. (B) Whereas in the presence of BBT (green spheres) that binds close to the FMN site (red spheres), it shows electron acceptance from NADH, thus hindering the overall pathway of electron transfer and ATP generation, resulting to an increase in ROS production. NADH: nicotinamide adenine dinucleotide hydrogen, and ATP: adenosine triphosphate.