Table 1. Anticonvulsant Effects of LTG–SB–M Complexes in PTZ-Induced Convulsions in Micea.
| compound | latency time (sec) | average duration of seizure (sec) | seizure score (counts) | mortality (counts) |
|---|---|---|---|---|
| 4a | 145.0 ± 23.4** | 86.5 ± 5.0*** | 15.0 ± 4.9** | 0.0 |
| 5a | 170.0 ± 45.2** | 81.5 ± 2.1*** | 11.0 ± 1.9** | 0.0 |
| 6a | 180.0 ± 75.9** | 105 ± 7.1** | 11.0 ± 2.3** | 1 |
| 7a | 220.0 ± 72.7*** | 110 ± 14.1** | 12.0 ± 1.2** | 0.0 |
| 4b | 240.0 ± 10.3*** | 81.5 ± 2.1*** | 10.0 ± 6.5*** | 0.0 |
| 5b | 250.0 ± 88.3*** | 97.5 ± 28.3*** | 11.0 ± 2.4** | 1 |
| 6b | 330.0 ± 67.8*** | 95 ± 10.5*** | 12.0 ± 1.8** | 0.0 |
| 7b | 190.0 ± 70.1** | 99 ± 7.1*** | 12.0 ± 1.5** | 0.0 |
| 4c | 250.0 ± 10.3*** | 81.5 ± 1.5*** | 14.0 ± 3.7** | 0.0 |
| 5c | 230.0 ± 70.1*** | 115 ± 10.0** | 10.0 ± 2.6*** | 0.0 |
| 6c | 376.7 ± 31.2*** | 110 ± 11.6** | 9.0 ± 0.8*** | 0.0 |
| 7c | 160.0 ± 49.0** | 125 ± 15.3* | 11.0 ± 1.6** | 0.0 |
| vehicle (V) | 0.00 | 0.00 | 0.00 | 0.0 |
| LTG control | 211.7 ± 98.1*** | 90 ± 3.5*** | 11.0 ± 2.3*** | 0.0 |
| PTZ control | 98.0 ± 21.7 | 155 ± 1.4 | 21.0 ± 0.0 | 6 |
a
Data are represented as mean ± SEM. n = 10. ***P < 0.001, **P < 0.01, and *P < 0.05 vs PTZ group as measure by One-Way Anova with Dunnett’s post hoc test.