Table 4. Binding Properties of Receptor Proteins to Different Ligands.

active compound	receptor	interacting protein (PDB ID)	efficacy	molecular formula	molecular weight (g/mol)	binding energy with receptor (kcal/mol)	inhibition constant (ki)	no. of hydrogen bonds	interacting residues
6c	VNaC	2KAV	anticonvulsant	C25H19AgCl2N5O4	632	–10.8	1.19	2	LYS1863, MET1842, ALA1860, LYS1863, LEU1866, GLY1867, GLY1870, GLU1871, MET1872, LEU1875
LTG (std.)	VNaC	2KAV	anticonvulsant	C9H7Cl2N5	256	–5.75	61.32	3	PRO1828, LEU1829, LEU1830, ILE1831, PHE1861, ARG1864, VAL1865
6c	DHFR	3GHW	anticancer	C25H19AgCl2N5O4	632	–11.38	4.57	2	ALA9, ILE16, LEU22, TRP24, GLU30, PHE34, THR56, SER59, ILE60, PRO61, VAL115, GLY117, TYR121
DOX (std.)	DHFR	3GHW	anticancer	C27H29NO11	543	–12.07	1.43	3	VAL3, ALA9, ILE16, ASP21, LEU22, PHE31, TYR33, PHE34, GLU39, SER59, ILE60