Table 1.
Baseline characteristics of included studies
| Study | Study design | Condition being treated | Total number of patients | Number of patients treated with EMDA | Length of follow-up (months) |
|---|---|---|---|---|---|
| Brausi 1998 | Multicenter, nonrandomized comparative study | NMIBC | 28 | 15 | Mean 16.3 (6-24) |
| Colombo 2001 | Single center, nonrandomized comparative study | NMIBC | 80 | 15 | 7-10 days |
| Decaestecker 2018 | Prospective cohort study | NMIBC | 32 | 32 | 2-4 weeks |
| Di Stasi 2003 | Prospective randomized comparative study | NMIBC | 108 | 36 | Median 45 |
| Di Stasi 2006 | Prospective randomized comparative study | NMIBC | 212 | 107 | Median 88 |
| Di Stasi 2011 | Multi center, randomized, parallel-group study | NMIBC | 374 | 124 | Median 86 |
| Gan 2016 | Prospective cohort study | NMIBC | 107 | 107 | 24 |
| Riedl 1998a | Prospective cohort study | NMIBC | 22 | 22 | Mean 14.1 |
| Racioppi 2018 | Prospective cohort study | NMIBC | 26 | 26 | Median 36 |
| Bach 2009 | Prospective cohort study | OAB | 84 | 84 | 8 weeks |
| Di Stasi 2001 | Prospective comparative study | OAB | 10 | 10 | N/A |
| Gauruder- Burmester 2008 | Prospective cohort study | OAB | 72 | 72 | 12 months |
| Kajbafzadeh 2011 | Prospective cohort study | OAB | 15 | 15 | 9 |
| Ladi-Seyedian 2018 | Prospective cohort study | OAB | 24 | 24 | 72 |
| Riedl 1998a | Prospective cohort study | OAB | 14 | 14 | 1 week |
| Koh 2019 | Prospective cohort study | OAB | 12 | 12 | 4-6 weeks |
| Gurpinar 1996 | Prospective cohort study | BPS/IC | 6 | 6 | |
| Gulpinar 2014 | Prospective randomized comparative study | BPS/IC | 31 | 16 | 24 |
| Riedl 1997 | Prospective cohort study | BPS/IC | 17 | 17 | Mean 10.8 |
| Riedl 1998a | Prospective cohort study | BPS/IC | 16 | 16 | Mean 10.8 |
| Riedl 1998b | Prospective cohort study | BPS/IC | 13 | 13 | Mean 10 |
| Rosamilia 1997 | Prospective cohort study | BPS/IC | 21 | 21 | 6 |
| Riedl 1998a | Prospective cohort study | Radiation cystitis | 6 | 6 | Mean 10.8 |
| Riedl 1997 | Prospective cohort study | Radiation cystitis | 6 | 6 | Mean 10.8 |
| Riedl 1998a | Prospective cohort study | Detrusor acontractility | 14 | 14 | 1 |
| Riedl 2000 | Prospective comparative study | Detrusor acontractility | 45 | 45 | 6 weeks |
| Dasgupta 1998 | Prospective cohort study | Anesthesia prior to transurethral procedures | 8 | 8 | Immediate assessment of pain following procedure |
| Fontanella 1997 | Prospective cohort study | Anesthesia prior to transurethral procedures | 91 | 91 | Immediate assessment of pain following procedure |
| Jewett 1999 | Multicenter comparative study | Anesthesia prior to transurethral procedures | 94 | 76 | Immediate assessment of pain following procedure |
| Riedl 1998a | Prospective cohort study | Anesthesia prior to transurethral procedures | 11 | 11 | Immediate assessment of pain following procedure |
| Rose 2005 | Retrospective comparative study | Anesthesia prior to transurethral procedures | 21 | 11 | Immediate assessment of pain following procedure |
| Schurch 2004 | Prospective comparative study | Anesthesia prior to transurethral procedures | 38 | 28 | Immediate assessment of pain following procedure |
EMDA: Electromotive drug administration, NMIBC: Nonmuscle-invasive bladder cancer, OAB: Overactive bladder, BPS: Bladder pain syndrome, IC: Interstitial cystitis