Supplementary Table 3.

Summary of studies evaluating the use of electromotive drug administration for detrusor acontractility

Study	Treatment regime	Comparator group	Outcome
Riedl 1998a	EMDA bethanechol hydrochloride 15-23 mA (10-30 mg in 150 ml saline 0.3%) for 20 min	EMDA saline and passive bethanechol	71.4% had increased intravesical pressure and detrusor contractions during treatment
Riedl 2000	EMDA bethanechol 20 mA (20 mg in 150 ml sodium chloride 0.3%)	Intravesical 20 mg bethanechol in 150 ml 0.3% saline; 25 mg oral bethanechol OD	Mean pressure increase of 34 cm water during EMDA in 24 patients, and in 9/11 of these who also received oral bethanechol spontaneous voiding was also restored. Spontaneous voiding was not restored in patients who did not have an increased pressure during the EMDA treatment

EMDA: Electromotive drug administration, OD: once daily