Table 5. Definition of treatment-refractory AD and recurrent AD.

Treatment refractory AD is defined as an AD who failed to reach to EASI50 or at least one of the following conditions after

3 months of appropriate treatment:

a. Daytime or nighttime Itch with NRS score ≥4

b. DLQI ≥6

Recurrent AD is defined as an AD who has developed at least moderate severity of AD lesions within 3 months after cessation of appropriate treatment.

AD: atopic dermatitis, EASI: eczema area and severity index, NRS: numerical rating scale, DLQI: dermatology life quality index.