Table 2. The production of 1-deoxyceramide after X-ray irradiation.
X-ray dose (Gy) | Irradiation time (h) | N-acyl chain length | |||||
---|---|---|---|---|---|---|---|
C16 | C18 | C20 | C22 | C24 | C24:1 | ||
3 | 0 | 12.80±1.03 | 3.95±0.24 | 3.62±0.34 | 2.80±0.22 | 13.76±1.05 | 12.28±1.13 |
12 | 14.41±1.41 | 4.85±0.75 | 3.71±0.25 | 5.46±0.58 | 13.33±0.94 | 12.69±1.56 | |
18 | 15.50±1.21** | 4.96±0.34 | 3.71±0.34 | 6.49±0.45 | 16.30±1.21 | 15.68±1.09*** | |
24 | 17.11±1.07*** | 6.05±0.75** | 6.57±0.69*** | 6.28±0.69*** | 27.98±1.53*** | 17.07±0.46*** | |
6 | 0 | 13.26±1.24 | 3.08±0.33 | 2.65±0.53 | 2.86±0.25 | 11.58±1.03 | 11.75±1.04 |
12 | 15.80±1.08 | 5.34±0.42 | 3.57±0.43 | 5.20±0.13 | 16.12±1.29** | 13.20±0.25 | |
18 | 20.80±1.98*** | 6.63±0.78*** | 5.06±0.65 | 6.41±0.87*** | 22.42±1.22*** | 16.34±1.98* | |
24 | 22.52±3.87*** | 7.51±0.54*** | 8.17±1.09*** | 8.58±0.48*** | 32.14±2.52*** | 23.9±3.25*** |
Values are presented as mean±standard deviation (pmol/mg). *p<0.05, **p<0.01, and ***p<0.001 compared to untreated normal human epidermal keratinocytes.