Table 3. The production of 1-deoxydihydroceramide after X-ray irradiation.
X-ray dose (Gy) | Irradiation time (h) | N-acyl chain length | |||||
---|---|---|---|---|---|---|---|
C16 | C18 | C20 | C22 | C24 | C24:1 | ||
3 | 0 | 24.66±2.04 | 6.43±0.25 | 3.06±0.29 | 4.29±0.49 | 2.05±0.31 | 1.78±0.18 |
12 | 23.15±1.09 | 6.75±0.84 | 3.63±0.48 | 3.52±0.26 | 2.15±0.25 | 1.93±0.18 | |
18 | 24.01±1.87 | 7.54±0.36 | 3.72±0.36 | 3.69±0.36 | 2.24±0.21 | 1.69±0.24 | |
24 | 27.99±1.94 | 10.35±0.75*** | 3.04±0.33 | 4.59±0.47 | 3.63±0.37*** | 1.72±0.33 | |
6 | 0 | 23.58±1.83 | 6.88±0.42 | 3.15±0.34 | 3.00±0.16 | 3.09±0.24 | 1.59±0.36 |
12 | 26.35±2.52 | 7.42±0.45 | 2.86±0.21 | 3.20±0.21 | 3.96±0.45 | 1.69±0.25 | |
18 | 28.50±2.84 | 9.42±1.21 | 3.49±0.51 | 3.61±0.33 | 4.08±0.41 | 1.27±0.11 | |
24 | 30.93±3.21** | 11.61±1.25*** | 3.44±0.41 | 5.47±0.46*** | 5.20±0.58** | 2.80±0.14 |
Values are presented as mean±standard deviation (pmol/mg). **p<0.01, and ***p<0.001 compared to untreated normal human epidermal keratinocytes.