Fig. 3. Polydeoxyribonucleotide (PDRN) decreases wound area and wound depth in diabetic mice. (A) Color-coded surface topography image captured by a PRIMOS^LITE optical 3D skin measuring device, (B) graph showing changes in wound area over time after injury. In +Lepr^db/+Lepr^db mice, the reduction of the wound area in the PDRN-injected group occurred more rapidly than in the phosphate-buffered saline (PBS)-injected group. In both ^m+/+Lepr^db mice and +Lepr^db/+Lepr^db mice, the wound area decreased faster than in controls, but this difference was not significant. (C) Graph showing changes in wound depth over time after injury. The PDRN-injected +Lepr^db/+Lepr^db mice recovered at a rate similar to that of PDRN-injected ^m+/+Lepr^db mice, but the recovery of the wound depth was delayed in the PBS-injected +Lepr^db/+Lepr^db mice. The wound depth of the PBS-injected group was significantly different from that of the PDRN-injected group on days 6 and 9 (^*p<0.05) in +Lepr^db/+Lepr^db mice.