Table 1. pDCs presence and MxA expression in pemphigus versus pemphigoid group (%).
Entity (case no.) | Age (yr) | Gender (ratio) | Frequency of pDC infiltration | pDC score* | MxA score† | |||||
---|---|---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 0 | 1 | 2 | ||||
Pemphigus (n=46) | 6~81 | 20 M:26 F | 46 | 0 | 16 | 29 | 1 | 0 | 44 | 2 |
Pemphigoid (n=32) | 47~91 | 14 M:18 F | 23 | 9 | 17 | 6 | 0 | 9 | 23 | 0 |
p-value‡ | - | - | <0.05 | <0.05 | <0.05 |
pDCs: plasmacytoid dendritic cells, MxA: myxovirus resistance A, M: male, F: female. *BDCA2+ pDC content was scored as percentage of total mononuclear infiltrate: 0 (no positive cells), 1 (1%~10% positive cells), 2 (10%~50% positive cells), 3 (>50% positive cells). †MxA staining was scored as: 0=negative, 1=patchy/weak, and 2=diffuse. ‡Statistical analysis was performed by using the Mann-Whitney test to analyze statistical differences in pDC and MxA scores between the 2 groups. A two-tailed p-value of <0.05 was considered statistically significant. Normal skin tissue served as negative control and cutaneous lupus erythematosus served as positive control.