Fig. 4.

Levels of pro-inflammatory cytokines secreted by macrophages following stimulation with LPS in the presence or absence of CRYAB. Concentration of IL-6 (a, e), IL-1β (b, f), IL-12p40 (c, g), and TNF-α (d, h) secreted by peritoneal macrophages from WT (white bars) and Cryab^−/− (black bars) animals following 24 h (a–d) and 48 h (e–h) stimulations with LPS and treatment with a CRYAB peptide; representative of 2 experiments for 24 h and 3 experiments for 48 h, n=4 mice/genotype with 6 wells/group. Data represent mean ± sem, *p< 0.05 independent t-test