Table 1.

Common cell processes defective in LSDs that may be impacted by CB1/CB2 modulator drugs

Cell function	Reference example
Autophagy	[39]
Calcium homeostasis	[40]
Cell survival/death	[41]
Endo/exocytosis (vesicular transport)	[42]
Endothelial cell function (BBB integrity)	[43]
Extracellular matrix production/fibrosis	[44]
Inflammation	[21]
Mitochondrial function/energy balance	[45]
Myelination	[46]
Synaptic function	[47]