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. 2021 Mar 24;23:39. doi: 10.1186/s13058-021-01417-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The effect of attenuated TGFB signalling on macrophage abundance and location in the mammary gland. Representative F4/80 antibody staining of macrophages around the ductal (a–c) and alveolar (d–f) epithelium. Examples of F4/80-positive epithelial cell-associated macrophages are indicated by arrows, and examples of F4/80-positive stromal macrophages are indicated by arrowheads. The number of F4/80-positive cells within the ductal epithelium and stroma (g) and within the alveolar epithelium and stroma (h) was calculated in the mammary glands from doxycycline-treated single transgenic control Cfms-rtTA (n = 10; a, d) mice, TetO-TbrII (n = 8; b, e) mice and double transgenic Cfms-TbrII (n = 12; c, f) mice. Data are presented as mean + SEM with statistical analysis using a one-way ANOVA test, *p < 0.05, **p < 0.01