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. 2021 Mar 24;23:39. doi: 10.1186/s13058-021-01417-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — The effect of attenuated TGFB signalling in macrophages on mammary gland cancer susceptibility in mice. Mammary tumour latency was monitored following DMBA administration in doxycycline-treated Cfms-rtTA, TetO-TbrII and Cfms-TbrII mice (n = 19–20/gp). Mice were palpated weekly, commencing 1 week after the final DMBA dose, with the zero time point representing mice 12 weeks of age. Tumour latency was determined as the time to the first appearance of palpable mammary tumour. The censored mice (mice were killed because of other tumours or sickness) were represented by a vertical line on the plot. Data are presented as Kaplan-Meier tumour-free survival plot (a). Significant difference observed by log rank analysis (Cfms-rtTA vs. Cfms-TbrII; p < 0.05 and TetO-TbrII vs. Cfms-TbrII; p < 0.05). Examples of F4/80 (b–e) and CCR7 (f, g) staining in tumours classified as glandular adenocarcinoma (b, c), carcinosarcoma (d, e) and solid adenocarcinoma (f, g), in tumour samples from Cfms-rtTA (b, d, f), TetO-TbrII (g) and Cfms-TbrII (c, e) mice