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. 2020 Aug 13;23(3):412–421. doi: 10.1093/neuonc/noaa189

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Fig. 4 — Intratumor FC stratifies overall survival in GBM patients. (A) ROI derived FC: Overall survival in GBM patients with low intratumor FC are compared with patients with high intratumor FC. Asterisk indicates significant difference (right-tailed Wilcoxon rank sum, W = 240, P < 0.001, Bonferroni corrected). (B) ROI derived FC: Kaplan–Meier survival analysis comparing overall survival in low intratumor FC GBM patients and high FC patients. Patients with high intratumor FC had a significantly longer overall survival than those with low intratumor FC (HR: 0.25, 95% CI: 0.11–0.58, P = 0.0011). (C) Voxelwise derived FC: Overall survival in GBM patients with low intratumor FC are compared with patients with high intratumor FC (right-tailed Wilcoxon rank sum, W = 281, P = 0.11, Bonferroni corrected). (D) Voxelwise derived FC: Kaplan–Meier survival analysis comparing overall survival in low intratumor FC GBM patients and high FC patients. Patients with high intratumor FC had a significantly longer overall survival than those with low intratumor FC (HR: 0.45, 95% CI: 0.21–0.98, P = 0.044).