Table 2.
Endpoint | RT Dose Metric | n a | Variable | Estimate | Standard Error | P-value | q-Valuec |
---|---|---|---|---|---|---|---|
FSIQ | Right temporal lobe mean | 68 | β 0 (intercept) | 92.08 | 2.22 | <0.0001 | |
β 1 (ageb × time) | 0.09 | 0.06 | 0.18 | ||||
β 2 (VP shunt) | −10.18 | 4.39 | 0.023 | ||||
β 3 (dose × time) | −0.05 | 0.02 | 0.00073 | 0.0048 | |||
PRI | Right temporal lobe mean | 69 | β 0 (intercept) | 93.89 | 2.32 | <0.0001 | |
β 1 (ageb × time) | 0.03 | 0.08 | 0.71 | ||||
β 2 (VP shunt) | −9.40 | 4.56 | 0.043 | ||||
β 3 (dose × time) | −0.04 | 0.02 | 0.036 | 0.26 | |||
PSI | Supratentorial brain D50 | 67 | β 0 (intercept) | 88.10 | 2.15 | <0.0001 | |
β 1 (ageb × time) | 0.16 | 0.07 | 0.029 | ||||
β 2 (VP shunt) | −9.21 | 4.14 | 0.03 | ||||
β 3 (dose × time) | −0.10 | 0.03 | 0.00032 | 0.0059 | |||
VCI (model A) | Right hippocampus D50 | 69 | β 0 (intercept) | 97.47 | 2.23 | <0.0001 | |
β 1 (ageb × time) | 0.09 | 0.08 | 0.23 | ||||
β 2 (VP shunt) | −9.09 | 4.39 | 0.042 | ||||
β 3 (dose × time) | −0.04 | 0.01 | 0.0019 | 0.0095 | |||
VCI (model B) | Left hippocampus D50 | 69 | β 0 (intercept) | 97.45 | 2.24 | <0.0001 | |
β 1 (ageb × time) | 0.10 | 0.08 | 0.22 | ||||
β 2 (VP shunt) | −8.91 | 4.42 | 0.048 | ||||
β 3 (dose × time) | −0.04 | 0.01 | 0.0021 | 0.0095 | |||
WMI | Supratentorial brain D50 | 68 | β 0 (intercept) | 95.32 | 2.15 | <0.0001 | |
β 1 (ageb × time) | 0.14 | 0.07 | 0.055 | ||||
β 2 (VP shunt) | −7.05 | 4.20 | 0.098 | ||||
β 3 (dose × time) | −0.10 | 0.03 | 0.00012 | 0.0014 |
*Negative estimates indicate a decrease in the intelligence score. The equation for calculating endpoints is presented as Model 2 in the Materials and Methods section.
a Number of patients evaluable in each model.
b Age at RT, in years.
c P-value adjusted for multiple comparisons.