Skip to main content
. 2020 Sep 16;23(3):487–497. doi: 10.1093/neuonc/noaa217

Table 2.

Coefficients for longitudinal models evaluating intelligence endpoints*

Endpoint RT Dose Metric n a Variable Estimate Standard Error P-value q-Valuec
FSIQ Right temporal lobe mean 68 β 0 (intercept) 92.08 2.22 <0.0001
β 1 (ageb × time) 0.09 0.06 0.18
β 2 (VP shunt) −10.18 4.39 0.023
β 3 (dose × time) −0.05 0.02 0.00073 0.0048
PRI Right temporal lobe mean 69 β 0 (intercept) 93.89 2.32 <0.0001
β 1 (ageb × time) 0.03 0.08 0.71
β 2 (VP shunt) −9.40 4.56 0.043
β 3 (dose × time) −0.04 0.02 0.036 0.26
PSI Supratentorial brain D50 67 β 0 (intercept) 88.10 2.15 <0.0001
β 1 (ageb × time) 0.16 0.07 0.029
β 2 (VP shunt) −9.21 4.14 0.03
β 3 (dose × time) −0.10 0.03 0.00032 0.0059
VCI (model A) Right hippocampus D50 69 β 0 (intercept) 97.47 2.23 <0.0001
β 1 (ageb × time) 0.09 0.08 0.23
β 2 (VP shunt) −9.09 4.39 0.042
β 3 (dose × time) −0.04 0.01 0.0019 0.0095
VCI (model B) Left hippocampus D50 69 β 0 (intercept) 97.45 2.24 <0.0001
β 1 (ageb × time) 0.10 0.08 0.22
β 2 (VP shunt) −8.91 4.42 0.048
β 3 (dose × time) −0.04 0.01 0.0021 0.0095
WMI Supratentorial brain D50 68 β 0 (intercept) 95.32 2.15 <0.0001
β 1 (ageb × time) 0.14 0.07 0.055
β 2 (VP shunt) −7.05 4.20 0.098
β 3 (dose × time) −0.10 0.03 0.00012 0.0014

*Negative estimates indicate a decrease in the intelligence score. The equation for calculating endpoints is presented as Model 2 in the Materials and Methods section.

a Number of patients evaluable in each model.

b Age at RT, in years.

c P-value adjusted for multiple comparisons.