Fig. 4.

Summary of secondary endpoints and cytokine analysis. Representative MRI of prolonged partial responders (A) and partial responders (B). Tumor volumes in dogs classified as nonresponders (C) and responders (D), with corresponding KPS appearing above each plotted tumor volume. Blue KPS indicates an SAE occurred in proximity; red KPS represents PD; CED repeated where KPS appears in green. ^necropsy performed; *withdrew from trial. Engel seizure outcomes (E) were superior in partial responders compared with dogs with stable or progressive disease. Comparisons of serum cytokines (mean ± SE) between control and glioma dogs (top panels) and between controls, responders, and nonresponders (bottom panels) on day 42.