Table 1.

Canine subject demographics, tumor characteristics, quantitative CED treatment parameters, and outcomes

Dog- Dose Cohorta	Breed	Age (yrs)	Body Weight (kg)	Sex	Baseline KPS	Diagnosis	Total Target Volume (Vt, cm3)	Contrast Enhancing Target Volume (cm3)	Infusion Volume (Vi, µL)	Distribution Volume (Vd, cm3)	Vd:Vi	Number of Catheters	Target Coverage (T)/% T = Vt∩Vd/ Vt	Target Containment (C)/% C = Vt∩Vd/Vd	Infusion Duration (min)	Total Cytotoxin Dose Delivered (µg)	Cytotoxin Dose/ Total Target Volume (µg/mL)	Maximum Objective Tumor Response	PFS (Days)	OS (Days)
1-0.05	Boston Terrier	10	13	M	65	HGA	0.68	0	493*	0.74	1.5	3	94	86	121	0.05	0.074	NA	NA	1
2-0.05	Boston Terrier	8	13	FS	65	HGO	3.47	0	403*	2.68	6.6	2	76	98	132	0.04	0.012	SD	139	244
3-0.05	Mixed breed	5	42	MN	70	HGA	2.51	0.68	374*	2.53	6.8	1	84	94	149	0.04	0.016	SD	47	47
4-.01	Catahoula Leopard	5	22	F	75	HGO	1.94	0.86	511*	1.42	2.9	2	72	98	125	0.10	0.052	PR	356	371
5.i-0.1	Boxer	6	22	FS	90	HGO	3.43	0.95	570*	1.94	3.4	1	55	97	115	0.11	0.032	PR	195	251
5.ii-0.2	Boxer	6	22	FS	90	HGO	1.51	0.59	371*	1.71	4.6	2	52	46	179	0.15	0.099	PR	NA	NA
6-0.1	English Bulldog	7	21	FS	70	HGO	6.49	0.41	1136*	3.04	2.7	5	46	98	390	0.23	0.035	SD	108	108
7-0.2	Am. Staff Terrier	6	25	FS	90	LGO	4.97	0	356*	2.23	6.2	5	40	90	126	0.14	0.028	SD	118	119
8-0.2	Boston Terrier	5	14	MN	80	LGA	3.59	1.65	286*	1.77	6.2	7	43	88	76	0.11	0.031	PR	189	202
9-0.4	French Bulldog	5	13	FS	80	HGA	10.04	0	1522*	6.96	4.6	7	66	95	269	1.22	0.122	SD	106	157
10.i-0.4	Am. Staff Terrier	6	36	MN	90	LGO	3.15	1.32	510*	2.26	4.4	1	70	97	139	0.41	0.130	PR	211	278
10.ii-0.8	Am. Staff Terrier	6	36	MN	90	LGO	3.22	0.57	366*	2.89	7.9	3	86	93	132	0.59	0.183	NA	NA	NA
11-0.4	Am. Staff Terrier	7	26	FS	80	LGO	2.26	0	270*	1.69	6.3	2	74	98	94	0.22	0.097	SD	114	117
12-0.4	Boxer	6	28	MN	80	HGA	3.10	0.28	741◊	3.71	5.0	4	93	76	171	0.59	0.190	SD	387	444
13-0.8	Boxer	9	43	MN	90	LGA	3.15	1.16	994◊	2.92	2.9	2	85	92	174	1.59	0.403	PR	167	167
14-0.8	Portuguese Water Dog	10	21	FS	90	LGU	1.60	0.24	396◊	1.83	4.6	2	92	80	71	0.31	0.194	PR	>767	>767
15-1.6	Boxer	8	31	MN	90	HGA	2.61	0.13	258◊	1.57	6.1	2	58	95	68	0.83	0.318	SD	99	224
16-1.6	Boxer	10	31	FS	90	HGO	1.69	0.42	674◊	0.99	1.5	8	52	88	151	2.16	1.278	PR	323	493
17-1.6	Boxer	5	43	FS	90	LGO	4.09	0	656◊	2.70	4.1	2	55	84	98	2.10	0.513	PR	274	314
Median	NA	7	25	NA	90	NA	3.15	0.41	493	2.28	4.6	2	70	92	132	0.23	0.099	NA	187	224

^aDose cohort = μg of each cytotoxin/mL of infusate

*CED infusion rates of 1–7.5 μL/min for individual catheters

^◊CED infusion rates of 1–20 μL/min for individual catheters

F, female

FS, female, spayed

HGA, high-grade astrocytoma

HGO, high-grade oligodendroglioma

KPS, Karnofsky performance score

LGA, low-grade astrocytoma

LGO, low-grade oligodendroglioma

LGU, low-grade undefined glioma

M, male

MN, male, neutered

NA, not applicable

OS, overall survival

PD, progressive disease

PFS, progression-free survival

PR, partial response

SD, stable disease