Table 3.

Summary of univariate Cox modeling of covariates for PFS

Covariate	Level	Hazard Ratio	95% CI		P-value
Age	< 45 vs ≥45	0.97	0.52	1.79	0.9186
Sex	Female vs male	0.72	0.39	1.35	0.3051
Race	Nonwhite vs white	0.82	0.29	2.32	0.7033
Histology grade	Grade I vs grade III/IV	0.60	0.24	1.52	0.2803
	Grade II vs grade III/IV	0.70	0.34	1.47	0.3484
Histology grade	Grade I/II vs grade III/IV	0.67	0.35	1.28	0.2241
Tumor location	Infratentorial vs spinal cord	1.77	0.73	4.27	0.2067
	Multiple regionsa vs spinal cord	2.60	0.34	20.11	0.3606
	Supratentorial vs spinal cord	1.77	0.88	3.55	0.1099
Karnofsky Performance Status	60–70 vs 100	0.52	0.20	1.32	0.1669
	80 vs 100	0.89	0.36	2.17	0.7968
	90 vs 100	0.41	0.18	0.95	0.0368
Karnofsky Performance Status	60–80 vs 90–100	1.20	0.64	2.25	0.5617
Number of prior treatments	1 vs 3	1.92	0.53	7.03	0.3234
	2 vs 3	1.18	0.58	2.38	0.6467
Age		0.99	0.97	1.01	0.4115
MDASI-BT/SP
Baseline activity-related interference score	0–10	0.98	0.88	1.11	0.8056
Baseline cognitive score	0–10	1.34	0.93	1.95	0.1171
Baseline neurologic score	0–10	1.20	0.77	1.87	0.4097
Baseline disease score	0–10	0.72	0.55	0.94	0.0178
Baseline autonomic score	0–10	0.88	0.71	1.10	0.2628

^aMultiple locations indicates that there were tumors located in multiple compartments at the time of diagnosis preventing the determination of the site of origin