Table 4.

Summary of univariate Cox modeling of covariates for OS

Covariate	Level	Hazard Ratio	95% CI		P-value
Age	<45 vs ≥45	0.47	0.22	1.01	0.0531
Sex	Female vs male	1.10	0.53	2.29	0.7916
Race	Nonwhite vs white	0.37	0.05	2.72	0.3272
Histology grade	Grade I vs grade III	0.48	0.16	1.46	0.1936
	Grade II vs grade III	0.54	0.23	1.29	0.1682
Histology grade	Grade I/II vs grade III	0.52	0.24	1.12	0.0958
Tumor location	Infratentorial vs spinal cord	1.81	0.63	5.21	0.2739
	Multiple regionsa vs spinal cord	4.93	0.60	40.16	0.1364
	Supratentorial vs spinal cord	1.89	0.83	4.32	0.1321
Karnofsky Performance Status	60–70 vs 100	1.53	0.49	4.85	0.4663
	80 vs 100	1.90	0.62	5.83	0.2625
	90 vs 100	1.02	0.35	2.98	0.9735
Karnofsky Performance Status	60–80 vs 90–100	1.69	0.82	3.46	0.1534
Number of prior treatments	1 vs 3	0.92	0.12	7.41	0.9405
	2 vs 3	0.86	0.39	1.90	0.7063
Age		1.01	0.99	1.04	0.2598
MDASI-BT/SP
Baseline activity-related interference score	0–10	1.09	0.95	1.24	0.2112
Baseline cognitive score	0–10	1.54	1.07	2.22	0.0212
Baseline neurologic score	0–10	2.14	1.22	3.76	0.0081
Baseline disease score	0–10	0.87	0.63	1.20	0.4052
Baseline autonomic score	0–10	1.00	0.78	1.29	0.9936

^aMultiple locations indicates that there were tumors located in multiple compartments at the time of diagnosis preventing the determination of the site of origin