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. 2021 Mar 19;47(5):86. doi: 10.3892/ijmm.2021.4919

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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LXA4 suppresses the activation of the PI3K/AKT pathway induced by PQ. Western blot analysis was performed to detect the protein levels of total-PI3K, p-PI3K, total AKT and p-AKT in (A and B) rat lung tissues and (C and D) RAW264.7 cells. Data are presented as the means ± SD (n=10 in vivo, n=6 in vitro). ^#P<0.05 vs. the CON group. ^*P<0.05 vs. the PQ group. ns, ns1, ns3, not significant (P>0.05) vs. the CON group; ns2, not significant (P>0.05) vs. the PQ group. LXA4, lipoxin A4; PQ, paraquat.