Table 1.
Sensitivity, specificity, positive and negative predictive value of rectal bleeding (RB) and stool frequency (SF) for endoscopic remission.
| Symptom Score | Time | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|
| Mayo Endoscopic Subscore = 0 or 1 | |||||
| RB | Week 8 | 83.9% (260/310) |
62.1% (315/365) |
57.5% (260/452) |
86.3% (315/365) |
| Week 38 | 95.0% (345/363) |
57.7% (262/454) |
64.2% (345/537) |
93.6% (262/280) |
|
| SF | Week 8 | 47.7% (148/310) |
80.4% (394/490) |
60.7% (148/244) |
70.9% (394/556) |
| Week 38 | 61.2% (222/363) |
70.7% (227/321) |
70.3% (222/316) |
61.7% (227/368) |
|
| RB+SF | Week 8 | 44.5% (148/310) |
86.4% (438/507) |
66.7% (138/207) |
71.8% (438/610) |
| Week 38 | 59.5% (216/363) |
82.2% (373/454) |
72.7% (216/297) |
71.7% (373/520) |
|
| Mayo Endoscopic Subscore = 0 | |||||
| RB | Week 8 | 91.5% (75/82) |
48.7% (358/735) |
16.6% (75/452) |
98.1% (358/365) |
| Week 38 | 96.4% (161/167) |
42.2% (274/650) |
30.0% (161/537) |
97.9% (274/280) |
|
| SF | Week 8 | 51.2% (42/82) |
71.9% (516/718) |
17.2% (42/244) |
92.8% (516/556) |
| Week 38 | 62.3% (104/167) |
59.0% (305/517) |
32.9% (104/316) |
82.9% (305/368) |
|
| RB+SF | Week 8 | 51.2% (42/82) |
77.6% (570/735) |
20.3% (42/207) |
93.4% (570/610) |
| Week 38 | 61.7% (103/167) |
70.2% (456/650) |
34.7% (103/297) |
87.7% (456/520) |
|
Sensitivity was defined as the proportion of patients with the criterion among all those with endoscopic remission. Specificity was defined as the proportion of patients without the criterion among all those without endoscopic remission. NPV negative predictive value was defined as the proportion of patients without endoscopic remission among all those with PRO subscores (RB, SF, or RB+SF) greater than 0; PPV positive predictive value was defined as the proportion of patients with endoscopic remission among all those with PRO subscores of 0.