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. 2021 Mar 11;12:631722. doi: 10.3389/fneur.2021.631722

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Copyright © 2021 Ibanez, Yokoyama, Possin, Matallana, Lopera, Nitrini, Takada, Custodio, Sosa Ortiz, Avila-Funes, Behrens, Slachevsky, Myers, Cochran, Brusco, Bruno, Brucki, Pina-Escudero, Okada de Oliveira, Donnelly Kehoe, Garcia, Cardona, Santamaria-Garcia, Moguilner, Duran-Aniotz, Tagliazucchi, Maito, Longoria Ibarrola, Pintado-Caipa, Godoy, Bakman, Javandel, Kosik, Valcour and Miller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The ReDLat initiative. Systematic comparisons between LAC and US samples of AD and FTD via a novel, multimodal approach. The multimodal patterns will be assessed with different measures of (A) genetic risk (Aim 1), (B) imaging markers boosted by computational approaches, and (C) harmonized and novel measures of cognitive profiles and SDH (Aim 2). These data sources will be (D) integrated and compared among countries through machine learning (Aim 3) to unveil the main commonalities and differences between US and LAC samples. Tier 1 (T1): Larger study (Aim 1 & 3). Tier 2 (T2, smaller study with deep neurocognitive investigation (Aim 2 & 3). D, Data; Q&F, Quality & feature extraction; N, normalization; T, test; VS, visualization; Neuropsychiatric E, Neuropsychiatric evaluations. Reproduced with authorization from (1).