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. 2021 Mar 24;12:208. doi: 10.1186/s13287-021-02264-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — NRF2 promotes function maturation of hiPSC-CMs. a Quantification of the percentage of siKEAP1 and siNC hiPSC-CMs proliferating, as measured by EdU (each biological replicate n > 5, three biological replicates). b The proportion of MyH6 to MyH7 was decreased in the siKEAP1 hiPSC-CMs. n = 3. c, d HiPSC-CMs were analyzed by calcium transient kinetics with Fluo-4 AM (n > 3 cells per condition, three biological replicates): c representative calcium transient and d calcium transient amplitude (F/F0). e Maximum calcium transient upstroke velocities. f Maximum calcium transient decay velocities. The means ± SEM are shown. **P < 0.01, ***P < 0.001, ****P < 0.0001