Table 2:
Adjusted hazard ratios (95% confidence intervals) for atherosclerotic cardiovascular disease by sleep apnea among patients with atrial fibrillation: MarketScan 2007–2014
| OSA ICD Only (Primary definition) | OSA ICD + CPT (More specific definition) | OSA Broad ICD (Less specific definition) | ||||
|---|---|---|---|---|---|---|
| No OSA | OSA | No OSA | OSA | No OSA | OSA | |
| N | 323,246 | 59,969 | 95,418 | 18,241 | 406,595 | 79,337 |
| Ischemic Stroke | ||||||
| N Events | 2,809 | 425 | 816 | 132 | 3,560 | 667 |
| Model 1a | Ref. | 0.43 (0.39, 0.48) | Ref. | 0.45 (0.38, 0.55) | Ref. | 0.45 (0.41, 0.49) |
| Model 2b | Ref. | 0.42 (0.38, 0.47) | Ref. | 0.42 (0.34, 0.50) | Ref. | 0.45 (0.41, 0.49) |
| Model 3c | Ref. | 0.48 (0.43, 0.53) | Ref. | 0.46 (0.38, 0.56) | Ref. | 0.52 (0.48, 0.57) |
| Myocardial Infarction | ||||||
| N Events | 4,116 | 523 | 1,193 | 160 | 4,748 | 707 |
| Model 1a | Ref. | 0.36 (0.33, 0.39) | Ref. | 0.38 (0.32, 0.45) | Ref. | 0.36 (0.33, 0.39) |
| Model 2b | Ref. | 0.35 (0.32, 0.38) | Ref. | 0.34 (0.29, 0.40) | Ref. | 0.35 (0.32, 0.38) |
| Model 3c | Ref. | 0.40 (0.37, 0.44) | Ref. | 0.38 (0.32, 0.45) | Ref. | 0.43 (0.39, 0.46) |
| Migraine | ||||||
| N Events | 673 | 153 | 219 | 55 | 659 | 223 |
| Model 1a | Ref. | 0.73 (0.61, 0.87) | Ref. | 0.86 (0.64, 1.2) | Ref. | 0.89 (0.76, 1.0) |
| Model 2b | Ref. | 0.73 (0.61, 0.88) | Ref. | 0.89 (0.65, 1.2) | Ref. | 0.83 (0.71, 0.97) |
| Model 3c | Ref. | 0.82 (0.68, 0.99) | Ref. | 0.90 (0.66, 1.2) | Ref. | 0.93 (0.79, 1.1) |
Abbreviations – OSA: obstructive sleep apnea, ICD: International Classification of Diseases, CPT: Current Procedural Terminology
a
Model 1 adjusted for age and sex
b
Model 2 added depression, alcoholism, diabetes, hypertension, sleep medications, anti-depressants, thyroid medication, weight-loss medication, anti-smoking medication, and inpatient and outpatient visits
c
Model 3 added continuous high dimensional propensity score