Table 5.

Total CRS and NE management costs by AE type and severity (N = 127)

Stratification	CRS only (n = 47)*			NE only (n = 14)*			Nonconcurrent CRS and NE (n = 21)*		Concurrent CRS and NE (n = 45)*
	Grade 1	Grade 2	Grade ≥3	Grade 1	Grade 2	Grade ≥3	Grade ≤2 CRS and NE	Grade ≥3 CRS or NE	Grade ≤2 CRS and NE	Grade ≥3 CRS or NE	Grade ≥3 CRS and NE
n (%)†	33 (26.0)	13 (10.2)	1 (0.8)	4 (3.1)	3 (2.4)	7 (5.5)	16 (12.6)	5 (3.9)	29 (22.8)	12 (9.4)	4 (3.1)
Median otal cost, $
Diagnostics	121	279	363	1 530	2 395	2 732	2 698	4 410	2 053	5 247	3 647
Medications	0	3 209	8 793	0	155	219	1 895	3 706	4 405	5 616	18 613
Procedures	0	0	13 741	0	0	0	0	0	0	0	20 861
Facility	7 395	14 525	38 330	399	14 525	14 658	17 278	50 836	26 762	57 817	134 221
Total	7 517	18 013	61 228	1 930	17 074	17 609	21 871	58 953	33 219	68 680	177 343
Summary cost statistics, $
Mean	11 042	21 750	61 228	1 963	28 508	22 670	26 296	64 481	50 903	106 714	187 058
SD	7 498	10 807	NA	2 136	31 445	16 783	13 555	33 240	80 375	109 590	159 971
Minimum	2 421	5 630	61 228	0	4 947	6 584	10 497	34 386	5 935	27 007	38 858
25th percentile	5 257	16 486	NA	179	10 654	9 893	16 752	34 672	25 911	45 833	54 869
75th percentile	14 768	28 050	NA	3 713	40 288	34 051	32 467	96 849	44 442	121 474	314 031
Maximum	37 616	46 972	61 228	3 992	64 214	48 485	61 925	102 728	454 093	432 675	345 689
95% CI per probabilistic sensitivity analysis‡
Lower	7 399	17 769	60 597	1 762	16 786	17 303	21 509	58 040	32 749	67 834	174 995
Upper	7 635	18 257	61 979	2 098	17 362	17 915	22 233	59 866	33 689	69 526	179 691

CI, confidence interval.

^*Lee et al¹² criteria were used to determine CRS toxicity grade, and National Cancer Institute Common Terminology Criteria for Adverse Events (version 4.03)¹⁷ were used to determine NE toxicity grade.

^†Percentages based on patients who experienced a CRS and/or NE episode.

^‡95% CIs estimated from probabilistic sensitivity analysis applied to base case median costs to impute 95% CIs for base case.