Table 4.

Factors for a diagnostic algorithm of pediatric ITP or non-IT

Structure of the algorithm may be based on:	Red flags defined as:
Occurrence or existence of risk factors (red flags) for secondary ITP (see the algorithm given in Figure 3)	Female
	Age >10 y
	Moderate thrombocytopenia >20 × 109/L
	Positive family history
	Comorbidities
	Nonresponse to first-line treatment
Duration of the disease and/or before treatment escalation
Response to treatment
Demographic characteristics, epidemiology, and geography
Needs of the patients, QoL
Costs, availability of tests, research questions
No algorithm but personalized, individual diagnostics

QoL, quality of life.