Table 3.

Laboratory findings and cytokines of interest between diseases during first KSHV-MCD flare on protocol

	Normal range or normal median (range)*	All patients	MCD alone	MCD with concurrent KS	P†	MCD with concurrent PEL ± KS	P†
Flare laboratory findings
Hemoglobin, g/dL	13.7-17.5	9.5 (8.0, 11.5)	10.3 (8, 11.3)	9.5 (7.9, 11.5)	.83	9.2 (8.4, 11.5)	.97
Platelets, ×103/µL	161-347	117 (59, 253)	90 (37, 344)	118 (70 184)	.93	195 (55, 347)	.94
Albumin, g/dL	3.5-5.2	2.7 (2.2, 3.3)	2.7 (2.1, 3.4)	2.9 (2.4, 3.4)	.67	2.5 (1.5, 3.0)	.24
CRP, mg/L	0-4.99	88.1 (19.3, 144)	97 (27.1, 195)	101.2 (14.5, 144)	.56	70.6 (50, 88.1)	.38
Flare, median (IQR)
IFN-γ, pg/mL	3.77 (0.64-14.4)	32.9 (15.6, 139.6)	30.9 (14.6, 97)	34.3 (18.4, 165)	.74	26.0 (14.6, 94.3)	.79
IL-10, pg/mL	0.2 (0.06-3.08)	100.8 (18.7, 730)	265.6 (44.4, 1290)	92.6 (9.2, 730)	.36	171.6 (39, 958.4)	.79
IL-12, pg/mL	0.29 (0.26-0.38)	0.2 (0.1, 0.3)	0.2 (0.1, 0.5)	0.1 (0.1, 0.3)	.42	0.2 (0.1, 0.3)	.46
IL-13, pg/mL	1.65 (0.6-2.78)	0.5 (0.1, 0.9)	0.6 (0.1, 1)	0.5 (0.1, 1)	.79	0.5 (0.1, 0.8)	.53
IL-1β, pg/mL	0.16 (0.11-24.3)	0.3 (0.2, 0.6)	0.3 (0.1, 0.6)	0.3 (0.2, 0.6)	.88	0.4 (0.2, 0.6)	.88
IL-2, pg/mL	0.52 (0.22-2.68)	0.6 (0.4, 0.9)	0.6 (0.4, 1)	0.4 (0.3, 0.9)	.68	0.8 (0.4, 1.2)	.42
IL-4, pg/mL	Not detectable	0.08 (0.06, 0.14)	0.1 (0.06, 0.20)	0.08 (0.05, 0.1)	.26	0.07 (0.06, 0.1)	.32
IL-6, pg/mL	0.47 (0.16-27.2)	8 (3.8, 25.8)	19 (4.2, 56.3)	6.8 (3.0, 15.9)	.12	8.3 (6.8, 31.0)	.74
IL-8, pg/mL	0.47 (0.16-27.2)	63.1 (19.3, 107.4)	86.1 (18.7, 157.9)	50 (19.3, 91.3)	.32	78.5 (28.8, 117.1)	.65
TNF-α, pg/mL	0.36 (0.10-1.75)	9 (6.5, 12.6)	9.4 (6.2, 12.4)	8.7 (7.1, 13.1)	.89	8.4 (6.5, 16.4)	.79
KSHV-VL, log10 copies/106 PBMCs	NA	3.8 (3.0, 5.1)	3.9 (3.0, 5.2)	3.9 (3.2, 5)	.78	3.7 (1.1, 4.2)	.65

NA, not available.

^*For cytokines, median and normal range are from 27 normal serum human samples tested in the proinflammatory panel 1 (human) kit.³²

^†P values are for comparisons with MCD alone.