Synergy was evaluated for low CD16A NK effector cell counts combined with low ADCC capacities. CFS family members, with CFS and without CFS, were compared to unrelated controls. Division of the quadrants was based on the median values of each variable. A. CX1:1. Data are from families #3, 10 & 28. B. CX-slopes. Data are from families #3, 10, 22 & 28. Ps <0.05 for family members in the low-low quadrants.