Table 2A.
Characteristics of the CFS Patients
| Donor numbere | Bateman Horne Center (BHC) Patient Historya | Rand36b Qs re Fatigue; 1 worse >3 | Rand36b (5 worse>1) | Postexertional Malaise (PEM)c | BHC Historya | Fibromyalgia Impact Questionnaired | DNA Sequence | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Family # | Gender | Agef | Age of first diagnosis | Duration of CFS, yrs | Q5g Lifting groceries | Q7h Climbing stairs | Q11i Difficulty, walk 1 block | General health Q36j | pem_onsetk : 1 minutes; 2 hours; 3 one day after | pem_durationl: 1 = 1 day; 2=several days; 3 = at least a week | Fibro-myalgia | Head aches | Unrefresh ed sleepm (100% worst) | Memoryn (100% worst) | Muscle paino (100% worst) | Balancep (100% worst) | CD16A Genotype | |
| 3 | 10 | M | 23 | 15 | 8 | 2 | 2 | 3 | 4 | 3 | 3 | Yes | No | 55 | 19 | 51.0 | 14 | F/F |
| 4 | 10 | M | 26 | 6 | 20 | 3 | 3 | 3 | 2 | 1 | 2 | No | No | 14 | 7 | 14.0 | 5 | F/F |
| 13 | 28 | F | 61 | 31 | 30 | 2 | 3 | 3 | 5 | 2 | 2 | Yes | No | 71 | 16 | 37.0 | 21 | F/F |
| 14 | 28 | F | 86 | 53 | 33 | 3 | 3 | 3 | 4 | 2 | 1 | No | Yes | 0 | 56 | 0.0 | 64 | V/F |
| 20 | 20 | F | 30 | 11 | 19 | 2 | 2 | 3 | 5 | 3 | 2 | No | Yes | 82 | 85 | 47.0 | 65 | F/F |
| 21 | 20 | F | 60 | 33 | 27 | 2 | 3 | 3 | 4 | 2 | 1 | No | Yes | 46 | 21 | 64.0 | 62 | F/F |
| 23 | 20 | F | 27 | 6 | 21 | 2 | 2 | 3 | 5 | 2 | 2 | Yes | Yes | 88 | 100 | 54.0 | 62 | F/F |
| 25 | 22 | F | 50 | 18 | 32 | 1 | 1 | 1 | 5 | 1 | 2 | Yes | Yes | 100 | 98 | 77.0 | 94 | F/F |
| 27 | 22 | F | 21 | 11 | 10 | 2 | 2 | 2 | 4 | 1 | 2 | Yes | Yes | 30 | 20 | 70.0 | 0 | F/F |
| 36 | 3 | F | 57 | 24 | 33 | 2 | 2 | 3 | 5 | 2 | 2 | Yes | Yes | 100 | 82 | 58.0 | 70 | F/F |
| 37 | 3 | F | 60 | 49 | 11 | 2 | 2 | 2 | 5 | 2 | 1 | Yes | Yes | 91 | 94 | 74.0 | 73 | F/F |
| Average | 46 | 23.4 | 22.2 | 2.1** | 2.3** | 2.6* | 4.4** | 1.9 | 1.8 | 64%α | 73%β | 61.5* | 54.4* | 49.6** | 48.2** | 91% F/F | ||
| std deviation | 21 | 16.4 | 9.5 | 0.5 | 0.6 | 0.7 | 0.9 | 0.7 | 0.6 | 35.2 | 38.1 | 24.4 | 31.9 | |||||
| median | 50 | 18 | 21 | 2 | 2 | 3 | 5 | 2 | 2 | 71 | 56 | 54 | 62 | |||||
| minimum | 21 | 6 | 8 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 7 | 0 | 0 | |||||
| maximum | 86 | 53 | 33 | 3 | 3 | 3 | 5 | 3 | 3 | 100 | 100 | 77 | 94 | |||||
| Table 2B. Characteristics of the Family Members without CFS | ||||||||||||||||||
| Number of donors | Family # | % F | Agef | NA | NA | Rand36b Qs re Fatigue; 1 worse >3 | Rand36b (5 worse>1) | NA | NA | BHC Historya | Fibromyalgia Impact Questionnaired | DNA Sequence | ||||||
| 22 | 3, 10, 20, 22, 28 | 55 | Q5g Lifting groceries | Q7h Climbing stairs | Q11i Difficulty, walk 1 block | General health Q36j (5 worse>1) | Fibro-myalgia | Head-aches | Unrefresh ed sleepm (100% worst) | Memoryn (100% worst) | Muscle paino (100% worst) | Balancep (100% worst) | CD16A Genotype | |||||
| Average | 46 | 2.9 | 2.9 | 3.0 | 2.3 | 0% | 23% | 35.5 | 25.3 | 10.0 | 1.9 | 82% F/F | ||||||
| std deviation | 15 | 0.4 | 0.3 | 0.2 | 1.3 | 31.4 | 25.8 | 11.5 | 3.4 | |||||||||
| median | 47 | 3.0 | 3.0 | 3.0 | 2.0 | 22.5 | 17.0 | 7.0 | 0.0 | |||||||||
| minimum | 21 | 2.0 | 2.0 | 2.0 | 1.0 | 0.0 | 0.0 | 0.0 | 0 | |||||||||
| maximum | 69 | 3.0 | 3.0 | 3.0 | 5.0 | 100.0 | 92.0 | 50.0 | 9 | |||||||||
P<0.05 &
P<0.01 by T-test
P<0.05 by Fisher exact test
P<0.05 by Chi square.
BHC data from patient records
Rand36 questionnaire
The Canadian Consensus Criteria defines Post-Exertional Malaise (PEM) as an inappropriate loss of physical and mental stamina, rapid muscular and cognitive fatigability.
Fibromyalgia Impact Questionnaire
Numbers assigned at site of ADCC assays.
Age at time of blood donation
Difficulty lifting or carrying groceries. 1, Yes, limited a lot; 2, Yes, limited a little; 3, No, not limited at all
Climbing one flight of stairs. 1, Yes, limited a lot ; 2, Yes, limited a little; 3, No, not limited at all
Walking one block. 1, Yes, limited a lot ; 2, Yes, limited a little; 3, No, not limited at all
My health is excellent. 1, Definitely true; 2, Mostly true; 3, Don’t know; 4, Mostly false; 5, Definitely false
Does PEM happen …1, minutes after exertion; 2, hours after exertion; 3, a day or more after exertion; 4, not at all
Duration How long does it take you to recover from PEM? 1, minutes after exertion; 2, hours after exertion; 3, a day or more after exertion; 4, not at all
Please rate the quality of your sleep. Slider scale, 0–100: Awoke well rested vs. Awoke very tired
Please rate your level of memory problems. Slider scale, 0 –100: Good memory vs. Very poor memory
Please rate your level of pain. Slider scale, 0 –100: No pain vs. Unbearable pain
Please rate your level of balance problems. Slider scale, 0 –100: No imbalance vs. Severe imbalance