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EC50 values [nM] of parental antibodies and bispecific Dab-Fc 2 × 3 molecule determined by ELISA-binding analysis
| HER2-His [nM] | HER3-His [nM] | HER2-Fc + HER3-His [nM] | |
|---|---|---|---|
| Trastuzumab | 0.45 ± 0.02 | n.d. | - |
| IgG 3–43 | n.d. | 0.21 ± 0.07 | - |
| Dab-Fc 2x3 | 1.1 ± 0.1 | 3.3 ± 0.4 | 4.1 ± 1.2 |
The bispecific and bivalent Dab-Fc 2 × 3 was titrated in the bifunctional binding of HER2 and HER3. n.d.: not determined; -: not performed; Mean ± SD, n = 3.
