Table 4.
Differentially expressed genes in placental tissue, ranked based on their significance, given by the FDR-corrected p-value (FDR). The β regression coefficient represents the fold changes in their gene expression in newborn girls compared to boys. Their chromosome locations are also provided
| Gene symbol | Gene name | β regr. coefficient | FDR | Genomic coordinates |
|---|---|---|---|---|
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | −3.53 | 1.16E-246 | chrY:15,027,862–15,027,921 |
| XIST | X inactive specific transcript (non-protein coding) | 8.24 | 8.21E-220 | chrX:73,040,565–73,040,506 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | −1.34 | 7.94E-104 | chrY:22,749,984–22,751,421 |
| GYG2P1 | glycogenin 2 pseudogene 1 | −2.49 | 2.10E-55 | chrY:14,518,023–14,517,964 |
| KDM5D | lysine (K)-specific demethylase 5D | −2.17 | 1.74E-47 | chrY:21,867,829–21,867,770 |
| TSIX | TSIX transcript, XIST antisense RNA | 2.66 | 5.35E-33 | chrX:73,043,015–73,043,074 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | 0.54 | 5.25E-21 | chrX:20,146,255–20,146,196 |
| HDHD1 | haloacid dehalogenase-like hydrolase domain containing 1 | 1.05 | 8.26E-21 | chrX:6,967,420–6,967,361 |
| TXLNGY | taxilin gamma pseudogene, Y-linked | −2.43 | 5.81E-20 | chrY:21,766,231–21,766,290 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.96 | 5.10E-16 | chrX:44,971,784–44,971,843 |
| CD99 | CD99 molecule | −1.13 | 7.78E-15 | chrX:2,638,454–2,640,715 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.53 | 1.12E-13 | chrX:41,208,627–41,208,686 |
| PCDH11X | protocadherin 11 X-linked | −1.29 | 9.96E-13 | chrX:91,134,246–91,134,305 |
| PCDH11Y | protocadherin 11 Y-linked | −1.24 | 1.08E-11 | chrY:4,968,462–4,968,521 |
| VAMP7 | vesicle-associated membrane protein 7 | −0.48 | 8.82E-10 | chrX:155,172,553–155,172,612 |
| STS | steroid sulfatase (microsomal), isozyme S | 1.01 | 3.66E-08 | chrX:7,271,727–7,271,786 |
| NAA10 | N(alpha)-acetyltransferase 10, NatA catalytic subunit | 0.36 | 2.07E-07 | chrX:153,197,847–153,197,788 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | 0.41 | 4.49E-06 | chrX:47,073,739–47,073,798 |
| HSD17B10 | hydroxysteroid (17-beta) dehydrogenase 10 | 0.35 | 7.30E-05 | chrX:53,458,440–53,458,381 |
| PRKY | protein kinase, Y-linked, pseudogene | −0.78 | 1.07E-04 | chrY:7,248,885–7,248,944 |
| ASMTL | acetylserotonin O-methyltransferase-like | −0.37 | 3.43E-04 | chrX:1,522,197–1,522,138 |
| SMC1A | structural maintenance of chromosomes 1A | 0.53 | 3.43E-04 | chrX:53,426,606–53,426,547 |
| KDM5C | lysine (K)-specific demethylase 5 C | 0.52 | 2.24E-03 | chrX:53,253,984–53,253,925 |
| DNM1P46 | DNM1 pseudogene 46 | −1.00 | 4.03E-03 | chr15:100,331,156–100,331,097 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | −0.76 | 5.20E-03 | chrX:100,809,416–100,809,475 |
| CDK16 | cyclin-dependent kinase 16 | 0.30 | 6.86E-03 | chrX:47,089,333–47,089,392 |
| TRERNA1 | translation regulatory long non-coding RNA 1 | 0.60 | 2.30E-02 | chr20:48,657,346–48,657,287 |